Tramadol and Acetaminophen
Tramadol and Acetaminophen is a combination of two pain relievers. Tramadol is a centrally acting opioid analgesic that binds to mu-opioid receptors and weakly inhibits the reuptake of norepinephrine and serotonin. Acetaminophen is a non-opioid, non-salicylate analgesic and antipyretic. Together, they provide synergistic pain relief for moderate to severe acute pain.
Dosage by Body Weight
For adults and adolescents 12 years and older (weighing 50 kg or more): The typical recommended dose is 1 to 2 tablets (37.5 mg tramadol / 325 mg acetaminophen per tablet) every 4 to 6 hours as needed for pain relief, up to a maximum of 8 tablets per day. Treatment should be limited to the shortest duration necessary. This combination is contraindicated in children under 12 years of age.
- Body Weight
- Below 5 kg
- Dose
- Contraindicated
- Frequency
- Do not use
- Tracking Notes
- Tramadol is strictly contraindicated in pediatric patients under 12 years of age due to the risk of life-threatening respiratory depression.
- Body Weight
- 5-7 kg
- Dose
- Contraindicated
- Frequency
- Do not use
- Tracking Notes
- Do not administer to infants or children. Increased risk of severe respiratory depression and death.
- Body Weight
- 8-10 kg
- Dose
- Contraindicated
- Frequency
- Do not use
- Tracking Notes
- Not approved or safe for pediatric use in this weight range.
- Body Weight
- 11-15 kg
- Dose
- Contraindicated
- Frequency
- Do not use
- Tracking Notes
- Do not use in children. Tramadol metabolism can vary unpredictably, leading to toxicity.
- Body Weight
- 16-20 kg
- Dose
- Contraindicated
- Frequency
- Do not use
- Tracking Notes
- Contraindicated. Safe use has not been established for children in this weight or age bracket.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Contraindicated | Do not use | Tramadol is strictly contraindicated in pediatric patients under 12 years of age due to the risk of life-threatening respiratory depression. |
| 5-7 kg | Contraindicated | Do not use | Do not administer to infants or children. Increased risk of severe respiratory depression and death. |
| 8-10 kg | Contraindicated | Do not use | Not approved or safe for pediatric use in this weight range. |
| 11-15 kg | Contraindicated | Do not use | Do not use in children. Tramadol metabolism can vary unpredictably, leading to toxicity. |
| 16-20 kg | Contraindicated | Do not use | Contraindicated. Safe use has not been established for children in this weight or age bracket. |
Formulation
Purpose
Short-term management of acute, moderate to moderately severe pain.
Generic Name
Tramadol Hydrochloride and AcetaminophenBranded Drug Names
Tramadol and Acetaminophen is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.